Sunday September 8, 2019

17.00 – Registration

18.00 – Welcome Reception with dinner buffet


Monday September 9, 2019

08.00-09.00 – Registration

09.00-09.15 – Welcome and Introduction
Rune Toftgård and Ulf De Faire

09.15-11.00 – Tissue stem cells as cancer cell of origin
Chair: Rune Toftgård

09.15-10.00 – Keynote: Hans Clevers (Hubrecht Institute, Utrecht, The Netherlands)
“Organoids as models of human cancer”

10.00-10.30 – Peter Dirks (University of Toronto, Canada)
“Heterogeneity and hierarchy in brain cancers”

10.30-11.00 – Cédric Blanpain (Université Libre de Bruxelles, Belgium)
“Identifying the cells of origin in skin cancers”

11.00-11.30 – Coffee break

11.30-13.00 – Importance of the niche in cancer initiation
Chair: Lena Claesson-Welsh

11.30-12.00 – David Scadden (Harvard University, Boston, USA)
“Primitive microenvironment sensing mechanism coopted in leukemia”

12.00-12.30 – Tomi Mäkelä (Helsinki University, Finland)
“The role of LKB1 as a tumor suppressor and maintenance of intestinal stem cells”

12.30-13:00 – Maria Kasper (Karolinska Institutet, Sweden)
“Decoding skin cancer formation via niche modulation and single-cell transcriptomics”

13.00-14.30 Lunch with Meet-the-Expert discussion sessions

14.30-16.00 – Dedifferentiation and cancer initiation
Chair: Ruth Palmer

14.30-15.00 – Florian Greten (University of Frankfurt, Germany)
“Cell plasticity in stemness and tumor progression”

15:00-15.30 – Christina Curtis (Stanford University, Stanford, USA)
“Towards forecasting tumor progression”

15.30-16.00 – Mohamed Bentires-Alj (University of Basel, Switzerland)
“Breast tumor heterogeneity and metastasis: Act locally, think globally“

16.00-16.30 – Coffee break

16.30-18.15 – Mechanisms of initiation and properties of initiated cells
Chair: Bengt Westermark

16:30-17.15 – Keynote: Sir Mike Stratton (Wellcome Sanger Institute, Cambridge, UK)
“Signatures of mutational processes in human cancer” 

17.15-17.45 – Mario Suvà (Harvard Medical School, Boston, USA)
“An integrative model of cellular states and genetics for glioblastoma”

17.45-18.15 – Kristian Pietras (Lund University, Lund, Sweden) “Microenvironmental control of the malignant phenotype in breast cancer”

19.00 – Boat trip and conference dinner with live music at Artipelag

Tuesday September 10, 2019

08.30-10.00 – The role of inflammation and wounding in cancer initiation
Chair: Martin Bergö

08.30-09.00 – Andreas Trumpp (Deutsches Krebsforschungszentrum, Heidelberg, Germany) “Stem cells features in cancer”

09.00-09.30 – Carla Kim (Harvard Medical School, Boston, USA) “Regulation of progenitor cells in the adult lung and in lung cancer”

09.30-10.00 – Jessica Strid (Imperial College London, London, UK) “A role for the IgE-FceRI axis in tumour immune-surveillance”

10.00-10.30 – Coffee break

10.30-12.00 – Clonal evolution: Cell of origin and cancer stem cells
Chair: Eva Hellström-Lindberg

10.30-11.00 – Leonard Zon (Harvard University, Boston, USA) “Cancer initiation in the zebrafish”

11.00-11.30 – Charles Swanton (The Francis Crick Institute, London, UK) Chromosomal order and chaos: Cancer evolution and immune evasion”

11.30-12.00 – Sten Eirik Jacobsen (Karolinska Institutet, Sweden) “Unravelling Lineage Potentials and Fates of Normal and Leukemic Stem and Progenitor Cells”

12.00-13.30 – Lunch with Meet-the-Expert discussion sessions

13.30-15.00 – Organoids and experimental models for cancer
Chair: Urbal Lendahl

13.30-14.00 – Jürgen Knoblich (Institute of Molecular Biotechnology, Vienna, Austria) “Metabolic reprogramming turns neural stem cells into brain tumor initiating cells”

14.00-14.30 – Toshiro Sato (Keio University School of Medicine, Tokyo, Japan) “4D-imaging of human colorectal cancer stem cells using organoid technology”

14.30-15.00 – Michael Shen (Columbia University Medical Center, New York, USA) “Investigating bladder cancer using patient-derived tumor organoids”

15.00-15.30 – Coffee break   15.30-17.00 – Early detection and cancer prevention
Chair: Sten Linnarsson

15.30-16.00 – Liran Shlush (Weizmann Institute of Science, Rehovot, Israel) Title TBA

16.00-16.30 – Thomas Würdinger (University Medical Center, Amsterdam, The Netherlands) Tumor-educated platelets for the detection of cancer”

16.30-17.00 – Daniel De Carvalho (University of Toronto, Canada) “Translation Aspects of DNA Methylation in Cancer” 

17.00-17.30 – Refreshments

17.30-19.15 – The impact of cell of origin on tumor phenotype, prognosis and therapeutic outcome
Chair: Jonas Bergh

17.30-18.15 –Keynote: John Dick (Princess Margaret Cancer Centre, University of Toronto, Canada) “Tracking the arc of AML and B-ALL from the cell of origin to the origin of relapse in a single blood sample”

18.15-18.45 – Charles Sawyers (Memorial Sloan Kettering Cancer Center, New York, USA) “Lineage Plasticity in Prostate Cancer”

18.45-19.15 – Sean Morrison (University of Texas Southwestern, Dallas, USA)
The metabolic regulation of cancer progression”

19.15-19.30 – Concluding remarks
Sten Eirik Jacobsen and Rune Toftgård

 

20.00 – Speaker’s Dinner at Skepparholmen Conference Hotel

Hosted by

Important dates

The application is now open!

Applications for participation in the Key 16 Origin of Cancer conference are welcome until February 17th, 2019
Please see the registration page for further details.

Professional Conference Organizer

For general information (registration, travel,
logistics etc.) kindly contact: key16@akademikonferens.se

Akademikonferens Direct +46 18 67 10 34 Switchboard +46 18 67 10 03

For scientific content (Conference application, program etc.) kindly contact: stratcan@ki.se